This work aimed at fabricating a gold leaf-based microfluidic device using xurography for analyzing the effect of EOs on its electrical properties using electrochemical impedance spectroscopy. The performance of the fabricated device was evaluated by measuring the change in its electrical resistance by injecting different concentrations (1% and 5%) of eucalyptus and peppermint EOs into the microchannel. The study demonstrated an increase in the electrical resistance of the chip with increased exposure time to EOs, measured at 0 h, 22 h, and 46 h. Moreover, the effect of concentration and individual properties of EOs on the electrical performance of the chip were also analyzed. The findings obtained in this paper are helpful in analyzing the effect of EOs on the fabricated microfluidic systems over the course of time that could provide a new approach for effective drug delivery in the field of dentistry. The work represents a novel proof-of-concept prototype; however, further studies are required for the complete atomization of the fabricated device in terms of developing a portable readout unit and flow rate control of the fluid inside the channels. Further work is needed to explore the design and components, optimization of fabrication and detection methodology, and analysis of the reactivity of various drugs within the system. Apart from the drug delivery applications, integrated microfluidic devices have been explored for various biomedical sensing applications such as pathogen detection, and single cell and cell culture analysis using impedance spectroscopy [38,39,40,41,42] (Table 4). The present work takes the initiative of detecting essential oils, which are also gaining enormous attention in medical applications suggesting a huge opportunity for their utilization in the coming time.
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